Through the Predictive Medicine Program, one of the three strategic axes of IMPaCT, a multipurpose population-based cohort will be established, integrating information on lifestyle, social and environmental context, clinical status, and many other factors.
This project is coordinated by the Consortium for Biomedical Research Center (CIBER) through its Public Health Epidemiology area (CIBERESP).
The principal investigator of the project is Marina Pollán Santamaría, the scientific director of CIBERESP and a researcher at the National Center for Epidemiology of the Carlos III Health Institute.
The IMPaCT Cohort is characterized by its large size, intensive use of information and communication technologies (ICTs), inclusion of a physical examination, environmental information collected from an extensive collection of biological samples, and periodic contacts with each participant over a span of 20 years.
It operates across 50 IMPaCT centers, primary healthcare centers belonging to the healthcare services of the 17 Autonomous Communities and Ceuta and Melilla. These centers handle recruitment, data collection, and periodic contact with participants.
The project gathers information from each participant through questionnaires, physical examinations, and the collection of various biological samples in the involved Health Centers. The data will be made available to the scientific community to develop other research projects of interest to society.
Territorial ManagersTo improve the understanding of the causes of diseases and health conditions that are priorities in public health, including age-related functional decline, injuries, and disabilities.
To monitor the health status of residents in Spain, with special attention to health inequalities (Precision Public Health).
To predict the risk of disease and other health conditions, including age-related functional decline, injuries, and disabilities (Precision Preventive Medicine).
To identify biomarkers of subclinical or early-stage diseases, as well as biomarkers of specific phenotypes potentially useful in clinical practice (Precision Clinical Medicine).
IMPaCT Cohort as a significant public health research infrastructure, will contribute to the effective deployment of Public Health and Precision Medicine within the National Health System. Therefore, the IMPaCT Cohort will benefit:
Thanks to the data from this study, the goal is to leverage the generated knowledge to enhance the health status of the entire resident population in Spain. On one hand, predictive models will be developed for use in preventive medicine. This prevention will be individualized and tailored based on environmental characteristics of the place of residence or socioeconomic position. On the other hand, it will aid in the early diagnosis of major diseases by identifying measurable biomarkers in blood or other easily accessible biological samples. Furthermore, therapeutic strategies will be enhanced through personalized treatment.
Participants will benefit from comprehensive health examinations conducted by IMPaCT staff. The test results will be evaluated by medical professionals, and any findings requiring medical attention will be communicated to the participants, facilitating access to healthcare. They will receive the results of blood sample analyses (complete blood count and biochemistry), along with the most relevant information from the physical examination.
The healthcare professionals involved in the project will be appointed as Associated Clinical Investigators of the IMPaCT Cohort. They will be part of the largest research study focused on Primary Care developed in Spain.
The IMPaCT Cohort will provide a vast amount of data to facilitate the development of new research proposed by the scientific community. A key element for this will be the extensive Biobank, enabling numerous analytical determinations over the coming decades to address new research inquiries.
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